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- As a control, a peptide of the same composition as the N-CAM decapeptide however of random sequence was infused on the contralateral side of the mind.
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When N-CAM and primary fibroblast growth factor, which is understood to stimulate astrocyte division in vitro, have been coinfused into cortical lesion websites, astrocyte proliferation was still inhibited. These outcomes recommend the hypothesis that, by reducing glial proliferation, N-CAM or its peptides might assist create an environment that is more suitable for neuronal regeneration. As of 2014, there have been more than 230 people in the wild in California, Arizona, and Baja California. The quantity has been rising steadily each year, as captive-bred birds are launched and wild pairs fledge young from their own nests.
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Janeczko K. The proliferative response of astrocytes to injury in neonatal rat brain. Janeczko K. The proliferative response of S-100 protein-positive glial cells to damage in the neonatal rat mind. Ssexs O, Edelman GM, Crossin KL. The neural cell adhesion molecule (N-CAM) inhibits proliferation in main cultures of rat astrocytes. The California Condor Recovery Program is a multi-entity effort, led by the U.S.
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We constantly discovered that the population of dividing astrocytes was significantly smaller on the facet in which N-CAM or one of many N-CAM-related molecules was infused than on the opposite aspect. The inhibition was best within the cortical lesion sites (approximately 50%) and was much less pronounced within the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a considerably smaller inhabitants of dividing astrocytes than the websites on the other side.
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